Search results for "candidate screening"

showing 1 items of 1 documents

CoverageAnalyzer (CAn): A Tool for Inspection of Modification Signatures in RNA Sequencing Profiles

2016

Combination of reverse transcription (RT) and deep sequencing has emerged as a powerful instrument for the detection of RNA modifications, a field that has seen a recent surge in activity because of its importance in gene regulation. Recent studies yielded high-resolution RT signatures of modified ribonucleotides relying on both sequence-dependent mismatch patterns and reverse transcription arrests. Common alignment viewers lack specialized functionality, such as filtering, tailored visualization, image export and differential analysis. Consequently, the community will profit from a platform seamlessly connecting detailed visual inspection of RT signatures and automated screening for modifi…

0301 basic medicineRNA modifications; reverse transcription; reverse transcription (RT) signature; RNA sequencing (RNA-Seq); Next-Generation Sequencing (NGS); candidate screening; alignment viewerNext-Generation Sequencing (NGS)lcsh:QR1-502[ SDV.BBM.BM ] Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biologyBiologycomputer.software_genre01 natural sciencesBiochemistryField (computer science)Differential analysisDeep sequencinglcsh:MicrobiologyArticleWorld Wide Web03 medical and health sciencesUser-Computer InterfaceRNA modificationsRNA sequencing (RNA-Seq)[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN]candidate screeningMolecular BiologyComputingMilieux_MISCELLANEOUS010405 organic chemistrySequence Analysis RNAGene Expression ProfilingRNAComputational BiologyHigh-Throughput Nucleotide Sequencing[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biologyreverse transcription (RT) signaturereverse transcriptionFile formatalignment viewer0104 chemical sciencesVisualizationVisual inspection030104 developmental biology[ SDV.BBM.GTP ] Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN]Data miningcomputerSoftwareBiomolecules
researchProduct